ET-743/Ecteinascidin/Yondelis + Doxil Trial
We met with the sarcoma medical
oncologist and her fellow at Fox Chase on 3/20/03. We found out the following:
|I probably can get on the trial! I need some tests done (liver enzymes) to
confirm, but previous blood work makes it look good. |
|Fox Chase has had at least 6 patients on the trial. 3 of these have been
sarcomas not responsive to the standard treatments; 2 of these became stable
on trial, and 1 had improvement. (They have received 6, 4, and 2 cycles.) They
are currently on the 2nd cohort of patients in the trial; they have received
600 micrograms/m^2 of ET-743, and 30 mg/m^2 of Doxil. I will be on the 3rd
cohort and will receive 750 micrograms/m^2 of ET-743, and 30 mg/m^2 of Doxil.
This will take 1 hour to receive the Doxil and 3 hours to receive the ET-743.
|The length of the cycle is 21 days. So, I will receive chemo every 21
days. I can go for 12-18 months as long as I stay stable or improve. The plan
is the same as before: 2 cycles, and a scan to see if there is disease
|We plan for me to start chemo on April 17. Due to the blood work that has
to be collected, I have to be in-patient for the first cycle. And, I will need
blood work done on the day after chemo, and the day after that. I also need
blood work on the 8th day after the chemo for the first 3 cycles. So, I will
have to go to Philly quite a bit in the next few months. |
|The most likely side effects from the ET-743 are fatigue, kidney functions
changes, elevated liver enzymes, and low white blood counts. The most likely
side effects from the Doxil are vomiting/nausea, fatigue, elevated liver
enzymes, low white blood counts, and mouth sores. I'll probably keep my hair.
To reduce the chance of liver problems, I will take a steroid (dexamethasone)
before and after the chemo. (Some of the drug-related deaths on previous phase
1 ET-743 trials were due to these liver problems.) |
|I will need baseline tests; ECHO, chest CT scan, and bloods. |
|I'll need a port installed. |
|The doctor wants me to have a brain MRI, an eye doctor appointment, and an
x-ray of my hip. |
My schedule of appointments was:
Based on the disease progression seen
in the CT scans on June 2, I am moving to another treatment.
listing of phase 1 trials at Fox Chase (search for "ET-743").